| Day | Date | Opponent | Location | TV | Outcome/Time |
| Sat | 09/02/2000 | Michigan | Ann Arbor, Mich. | ESPN Regional | L, 42-7
Recap | Stats |
Live Audio | Live Audio |
| Sat | 09/09/2000 | Pittsburgh | Bowling Green, Ohio
(Varsity BG/Hall of Fame/Black Swamp) | ESPN Regional | L, 34-16
Recap | Stats |
Live Audio |
| Sat | 09/16/2000 | Temple | Philadelphia, Pa. | ESPN Regional | L, 31-14
Recap | Stats |
Live Audio |
| Sat | 09/23/2000 | Buffalo* | Buffalo, N.Y. | | L, 20-17
Recap | Stats |
Live Audio |
| Sat | 09/30/2000 | Kent* | Kent, Ohio | | W, 18-11
Recap | Stats |
Live Audio |
| Sat | 10/07/2000 | Akron* | Bowling Green, Ohio
(Homecoming) | | L, 27-21
Recap | Stats |
Live Audio |
| Sat | 10/14/2000 | Miami (OH)* | Oxford, Ohio | | L, 24-10
Recap | Stats |
Live Audio |
| Sat | 10/21/2000 | Eastern Michigan* | Bowling Green, Ohio
(Pepsi Night) | | W, 20-6
Recap | Stats |
Live Audio |
| Sat | 11/04/2000 | Marshall* | Bowling Green, Ohio
(Family Weekend) | ESPN Regional | L, 20-13
Recap | Stats |
Live Audio |
| Sat | 11/11/2000 | Ohio* | Bowling Green, Ohio
(Faculty & Staff Day) | | L, 23-21
Recap | Stats |
Live Audio |
| Wed | 11/22/2000 | Toledo* | Toledo, Ohio | ESPN2 | L, 51-17
Recap | Stats |
Live Audio |
